Endocrine Abstracts

An 18 year old lady was seen in endocrine clinic in October 2004 with 10 month history of polyuria, polydypsia and lethargy. Previous medical history includes Graves thyrotoxicosis which is treated with carbimazole.Clinical examination was unremarkable.Investigations and management: Urine osmolality −84 mosmol (250–750), serum osmolality −290 mosmol (288–298), full blood count, fasting glucose, renal, liver fu...

Introduction: We present the outcome for the first 80 patients undergoing neuronavigation–guided, endoscopic transphenoidal surgery in our centre since August 2001. All operations were undertaken by the same neurosurgeon and endoscopic nasal surgeon.Indications for treatment: Indications for treatment may be divided into: Functioning microadenomas, with the aim of surgical cure while protecting residual pituitary function. Functioning macroadenomas,...

Introduction: The beneficial effect of GH replacement on bone in AGHD patients is mediated by improvements in target organ sensitivity to PTH and phosphocalcium metabolism. In aging women with established osteoporosis, GH and IGF-1 concentrations are lower and administration of GH has been shown to increase bone turnover and BMD, but the mechanisms remain unclear.Methods: Fourteen postmenopausal women (63.4±2.1 years; mean BMD T score ± ...

Mutations in the RET gene are responsible for Multiple Endocrine Neoplasia type 2A (MEN2A), characterised by Medullary Thyroid Carcinoma (MTC) and Pheochromocytoma (PCC). It is well recognised that there is a genotype-phenotype correlation regarding likelihood of endocrine tumour development. The American Thyroid Association (ATA) has published predictive grading to guide clinical management of patients with RET mutations.Aim: In this study, we aim to as...

Plasma and urine 18-hydroxycortisol ('18-OHF') measurements are helpful to discriminate primary hyperaldosteronism (Conn's syndrome) caused by adrenal hyperplasia (normal 18-OHF) from adrenal adenoma or glucocorticoid suppressible hyperaldosteronism ( raised 18-OHF). We have developed DELFIA time-resolved fluorescence assays for 18-OHF as a second-line biochemical investigation for patients with raised plasma aldosterone/ renin ratios. Following ether extraction, test samples ...

IntroductionParagangliomas (PGLs) are neuroendocrine tumours that arise from neural crest-derived chromaffin cells. They can develop anywhere these cells exist from the base of the skull to the pelvis. All PGLs have neuro-secretory potential and can produce symptoms due to catecholamine excess. While the majority are benign they do have malignant potential. Mediastinal PGLs are rare and often have a strong genetic predisposition. A higher proportion of t...

BackgroundNatural disasters resulting in psychosocial stress and endocrine imbalances are implicated for impacting sexual health. We postulate COVID-19 for its longer duration and global lockdown has implications on the sexual healthMethodsWe analysed contemporary protocols of six ongoing trials through WHO International Clinical Trials Registry Platform and www.clinicaltrials.gov trials registry database. Th...

Background: Unilateral adrenal haemorrhage is usually asymptomatic and picked up incidentally on CT imaging. However, adrenal haemorrhage can cause flank pain and when bilateral, adrenal insufficiency or adrenal crisis. Biochemical changes include electrolyte imbalances, low platelet count and anaemia. We report a case of unilateral adrenal haemorrhage with devastating outcome.Case: A 45-year-old male smoker was incident...

An underlying genetic/endocrine cause for severe hypospadias is found in up to 20% of affected boys as described in the literature, with environmental and epigenetic factors also believed to play a role. We conducted a retrospective analysis of 65 boys with severe hypospadias (penoscrotal, scrotal, perineal) managed by Paediatric Urology at Barts Health NHS Trust, born between January 2010 and 2021 (38% white caucasian, 28% asian, 22% black and 12% other/undefined). Boys with ...

Background: The NCYPDN plan describes a care model where children, young people (CYP) and families ‘co-design their care plan during appointments’ and ‘have a say in service planning.’ RCPCH ‘Voice Matters’ notes children want clinicians to ‘better understand how we are feeling, to ensure we’re involved in our treatment and have the support we need’. Our clinic experience found some CYP we...